The transgendered voice of reason in the Willis house, Ava is the only transwoman capable of tolerating Angie.
- DESCRIPTION: Quillsville’s well-known and well-established transwoman, former Quillsville Central High School basketball center (she scored most three pointers scored during high school)
- FULL NAME: Aeverine Melanie Florence Willis (born Frank Michael Willis)
- OCCUPATION: Saleswoman of retail and retail accessories with honor and dignity. Manager of Craven Gifts in Quillsville
- THE TWO WOMEN IN HER LIFE: Her wife Angie and her truck Marla.
- QUOTE: “Nobody likes a knowitall who sits around talking about their genitalia (his ding-dong or her ho-ho).”
- DREAM VACATION: All expenses paid month-long landscaping workshop at the Lawn Care Academy of America
- EMBARRASSING IMPERFECTION: An enlarged clitoris and having a boyfriend while attending Port Melissa Univeristy.
- VOICED BY: Ava Zinn (normal voice), Melvin Runecraft (evil voice), and Frank Davidson (pre-transition)
- FIRST APPEARANCE: “Pilot” (S01 E01)
Evolution
Ava Willis (2007-2018) 
Ava Willis (1999-2007) 
Ava Willis (as Frank, 1993-1998) 
Ava Willis (as Frank, 1988-1993) 
Ava Willis (as Frank, 1984-1988)
Family Members
Angie Willis 
Tom Willis 
Deanna Willis 
Heather Willis 
Shushu Willis 
Tabby Willis 
A.A. Willis 
Ron Willis 
Hillary Willis 
Luanne Willis 
Emilie Willis 
Brian Willis 
Stuart Willis 
Brynn Willis